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[Function of SIRT6 in tumor initiation and progression]
Zhen Dong1, Qian Lei1, Lichao Liu2
1College of Biotechnology, State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.
Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|October 12, 2017
Summary
SIRT6, a protein involved in aging and metabolism, plays a complex role in cancer development. It can act as a tumor suppressor or an oncogene, offering potential therapeutic targets.
Area of Science:
- Molecular Biology
- Biochemistry
- Cancer Research
Background:
- SIRT6 is a member of the sirtuin family (Class III histone deacetylases).
- It regulates critical biological processes like aging, metabolism, and DNA repair.
- Emerging evidence links SIRT6 to the initiation and progression of various cancers.
Purpose of the Study:
- To elucidate the multifaceted roles of SIRT6 in tumorigenesis.
- To summarize the mechanisms by which SIRT6 influences tumor initiation and progression.
- To identify potential therapeutic strategies targeting SIRT6 in cancer.
Main Methods:
- Literature review and analysis of existing studies on SIRT6 and cancer.
- Depiction of SIRT6's essential roles in tumor development.
- Summary of SIRT6's modes of action in various cancer types.
Main Results:
- SIRT6 exhibits a dual role in cancer, acting as both a tumor suppressor and an oncogene.
- Its involvement spans multiple cancer types, including hepatic, lung, breast, and genital system tumors.
- Specific mechanisms of SIRT6's action in cancer progression were identified.
Conclusions:
- SIRT6 is a critical factor in the initiation and progression of diverse tumors.
- Understanding SIRT6's dual function is crucial for developing effective cancer therapies.
- Targeting SIRT6 pathways may offer novel avenues for cancer treatment.
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