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Ocular Syphilis: An Update.

Parthopratim Dutta Majumder1, Elizabeth J Chen2, Janika Shah3

  • 1a Sankara Nethralaya , Medical Research Foundation , Chennai , Tamil Nadu , India.

Ocular Immunology and Inflammation
|October 12, 2017
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Summary
This summary is machine-generated.

Ocular syphilis, an old disease, is resurging, particularly in HIV-positive individuals. This review updates clinical presentation, diagnosis, and treatment for this challenging condition.

Keywords:
ChorioretintisHIVMasqueradeOcular syphilisUveitis

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Public Health

Background:

  • Recent resurgence in syphilis incidence, especially among HIV-positive individuals.
  • Ocular syphilis presents a diagnostic challenge due to varied manifestations and early onset.
  • Established link between HIV and syphilis, influencing disease progression.

Purpose of the Study:

  • To provide an updated review of ocular syphilis.
  • To cover clinical presentation, diagnosis, and treatment.
  • To highlight the evolving landscape of ocular syphilis.

Main Methods:

  • Literature review.
  • Synthesis of recent findings on ocular syphilis.
  • Analysis of the interplay between HIV and syphilis.

Main Results:

  • Ocular syphilis can manifest in diverse ways at any disease stage, commonly as panuveitis.
  • It can appear as early as 6 weeks post-transmission and be the sole presenting sign of systemic syphilis.
  • HIV co-infection complicates syphilis, increasing risks for neurosyphilis.

Conclusions:

  • Ocular syphilis requires heightened awareness due to its resurgence.
  • Early diagnosis and treatment are crucial, especially in co-infected patients.
  • Understanding the HIV-syphilis interaction is key for managing ocular manifestations.