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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic dermatitis: the new frontier.

Victoria R Harris1, Alan J Cooper2

  • 1Royal North Shore Hospital, Sydney, NSW Victoria.harris@health.nsw.gov.au.

The Medical Journal of Australia
|October 13, 2017
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) is a common inflammatory skin disease impacting quality of life. New targeted immunotherapies show promise for moderate to severe cases, offering new treatment options beyond traditional topical therapies.

Keywords:
Anti-inflammatory agentsAtopyDermatitisEczemaInflammation

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Area of Science:

  • Immunology
  • Dermatology
  • Translational Medicine

Background:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition affecting adults and children.
  • AD significantly diminishes patients' and families' quality of life.
  • Current treatments focus on reducing skin inflammation and itching with topical therapies, but some cases require oral immunosuppression.

Purpose of the Study:

  • To review the advancements in understanding the immune pathogenesis of atopic dermatitis.
  • To highlight the development of novel targeted immunotherapies for AD treatment.

Main Methods:

  • Review of current literature on AD pathogenesis and treatment.
  • Analysis of clinical trial data for new targeted immunotherapies.

Main Results:

  • Understanding T helper cell roles and inflammatory pathways has driven research.
  • New targeted immunotherapies, including IL-4, IL-13, IL-31, JAK, and PDE inhibitors, show promising results in clinical trials for moderate to severe AD.

Conclusions:

  • Advances in understanding AD's immune basis have led to innovative treatments.
  • Targeted immunotherapies represent a breakthrough for managing moderate to severe atopic dermatitis.