Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of bone formation within β-tricalcium phosphate scaffolds in a sheep scapular bioreactor model using micro-computed tomography analysis.

Regenerative biomaterials·2026
Same author

Advances in Differentiation of Induced Pluripotent Stem Cell-Derived Corneal Endothelial Cells: Pathway Insights and Evaluation of Characterization Practices.

The American journal of pathology·2026
Same author

Reducing the Carbon Footprint of Refractive Surgery Through Same-Day Postoperative Care.

Journal of cataract and refractive surgery·2026
Same author

Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Additive-Free Edge-Functionalized Graphene Dough.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

A New Bioprinted Dual-Layered Corneal Structure Using Collagen-Based Bioinks.

Tissue engineering. Part A·2026
Same journal

A review on assessment of advances in polymers and their hybrid nanosystem for leukaemia theranostics applications.

Biomedical materials (Bristol, England)·2026
Same journal

Controllable preparation of magnesium-hybridized PLA-PEG-PLA porous microspheres with anti-inflammatory function.

Biomedical materials (Bristol, England)·2026
Same journal

Core-shell fibrous threads loaded with VEGF plasmid polyplexes for sustained, threshold-guided gene delivery.

Biomedical materials (Bristol, England)·2026
Same journal

3-Layer lung cancer invasion model for evaluating MMP-targeted anti-metastatic therapeutics.

Biomedical materials (Bristol, England)·2026
Same journal

Enhancement of type H vessels in bone repair of rat tibial defects treated with stromal vascular fraction-collagen sponge composites.

Biomedical materials (Bristol, England)·2026
Same journal

Emulsion-based synthesis of polycaprolactone/bioactive glass 45S5 microparticles for bone regeneration applications.

Biomedical materials (Bristol, England)·2026
See all related articles

Related Experiment Video

Updated: Feb 21, 2026

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea
07:35

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

9.3K

Biomaterials for corneal bioengineering.

Zhi Chen1, Jingjing You, Xiao Liu

  • 1ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Squires Way, Fairy Meadow, New South Wales 2519, Australia.

Biomedical Materials (Bristol, England)
|October 13, 2017
PubMed
Summary
This summary is machine-generated.

Bioengineered corneas offer a promising solution to donor tissue shortages and transplant rejection. Research focuses on biomaterials for corneal regeneration, aiming for durable, transparent, and biocompatible synthetic tissues.

More Related Videos

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.9K
Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
05:20

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

8.4K

Related Experiment Videos

Last Updated: Feb 21, 2026

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea
07:35

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

9.3K
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.9K
Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
05:20

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

8.4K

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Corneal transplantation is a vital treatment for corneal diseases, but donor tissue scarcity and transplant rejection limit its success.
  • Bioengineering corneal tissue is emerging as a key strategy to overcome these limitations and restore vision.
  • Developing synthetic or semi-synthetic corneal substitutes is crucial for addressing the global need for corneal grafts.

Purpose of the Study:

  • To review the anatomy and function of the native cornea.
  • To evaluate various biomaterials for their potential in corneal regeneration.
  • To discuss the integration of cells with biomaterials for synthetic cornea fabrication.

Main Methods:

  • Review of existing literature on corneal anatomy, function, and biomaterials.
  • Analysis of key characteristics required for ideal corneal biomaterials (durability, biocompatibility, transparency, etc.).
  • Discussion on cellular integration with biomaterials for tissue engineering.

Main Results:

  • The native cornea's structure and function serve as a benchmark for evaluating biomaterials.
  • Several biomaterials are under investigation for their suitability in corneal regeneration.
  • Optimal integration of cells and biomaterials is critical for successful tissue fabrication.

Conclusions:

  • Bioengineered corneas hold significant potential for regenerative medicine, addressing donor shortages and transplant failure.
  • Understanding corneal requirements is essential for designing effective synthetic and semi-synthetic corneal substitutes.
  • These engineered tissues can be used for in vitro modeling, drug screening, and in vivo transplantation.