[Progress in omics research of Aspergillus niger]

Area of Science:

• Industrial biotechnology
• Microbial fermentation
• Systems biology

Background:

• Aspergillus niger is a key industrial strain for producing organic acids and enzymes.
• The increasing volume of omics data (genome, transcriptome, proteome, metabolome) signifies a big data era for A. niger research.

Purpose of the Study:

• To review and summarize the progress of omics research in Aspergillus niger.
• To propose future directions for omics research in A. niger as a cell factory.

Main Methods:

• Analysis of single omics data.
• Comparison of multi-omics data.
• Integration of multi-omics data with genome-scale metabolic network models.

Main Results:

• Multi-omics integration deepens the understanding of A. niger's efficient production mechanisms.
• This approach enables systematic optimization of strain performance through genetic modification and process regulation.

Conclusions:

• Omics technologies are crucial for advancing Aspergillus niger research.
• Future research should focus on integrating multi-omics data for enhanced strain engineering and process optimization.