Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
Allergic Reactions02:06

Allergic Reactions

Overview
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of hydrokinesitherapy on balance and walking ability for stroke survivors: update of a systematic review and meta-analysis of randomized controlled studies.

European journal of physical and rehabilitation medicine·2026
Same author

Soil organic carbon accumulation in response to vegetation restoration across global mining areas: A meta-analysis.

Journal of environmental management·2026
Same author

State-dependent repetitive transcranial magnetic stimulation in disorders of consciousness.

Frontiers in human neuroscience·2026
Same author

Unraveling the complex web of acute kidney injury: pathways, biomarkers, and future directions.

Jornal brasileiro de nefrologia·2026
Same author

The risk of congenital malformations and neonatal outcomes among singletons and twins born after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and Bayesian network meta-regression analysis.

BMC pregnancy and childbirth·2026
Same author

Extended transformation optics in anisotropic photonic devices: theory, design, and demonstrations.

Optics express·2026
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue (NALT) in Mouse Responses to Vaccines
12:21

Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue (NALT) in Mouse Responses to Vaccines

Published on: August 1, 2012

Alarmins and immunity.

De Yang1, Zhen Han1, Joost J Oppenheim1

  • 1Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD, USA.

Immunological Reviews
|October 14, 2017
PubMed
Summary
This summary is machine-generated.

Alarmins are crucial initiators of immune responses, impacting health and disease. This review explores their roles in immunity, inflammation, and cancer.

Keywords:
alarmindamage-associated molecular patterndendritic cellsimmune responsetumor immunity

More Related Videos

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Related Experiment Videos

Last Updated: Jul 2, 2026

Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue (NALT) in Mouse Responses to Vaccines
12:21

Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue (NALT) in Mouse Responses to Vaccines

Published on: August 1, 2012

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • The alarmin hypothesis, proposed over a decade ago, has evolved significantly.
  • Alarmins are now recognized as key players in numerous physiological and pathophysiological processes.

Purpose of the Study:

  • To provide a comprehensive overview of alarmin functions.
  • To highlight the involvement of alarmins in immune response induction and tumor immunity.

Main Methods:

  • Literature review and synthesis of existing research on alarmins.
  • Analysis of alarmin roles in innate and adaptive immunity.
  • Examination of alarmin contributions to oncogenesis and tumor immunity.

Main Results:

  • Alarmins initiate and participate in host defense, gene regulation, homeostasis, wound healing, inflammation, allergy, and autoimmunity.
  • Alarmins are critical for inducing both innate and adaptive immune responses.
  • Alarmins play a significant role in tumor immunity.

Conclusions:

  • Alarmins are versatile molecules with broad implications in health and disease.
  • Understanding alarmin functions is essential for developing novel therapeutic strategies in immunity and cancer.