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A Personalized Week-to-Week Updating Algorithm to Improve Continuous Glucose Monitoring Performance
Stamatina Zavitsanou1,2, Joon Bok Lee1, Jordan E Pinsker2
11 Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Background:
Continuous glucose monitoring (CGM) systems are increasingly becoming essential components in type 1 diabetes mellitus (T1DM) management. Current CGM technology requires frequent calibration to ensure accurate sensor performance. The accuracy of these systems is of great importance since medical decisions are made based on monitored glucose values and trends.
Methods:
In this work, we introduce a calibration strategy that is augmented with a weekly updating feature. During the life cycle of the sensor, the calibration mechanism periodically estimates the parameters of a calibration model to fit self-monitoring blood glucose (SMBG) measurements. At the end of each week of use, an optimization problem that minimizes the sum of squared residuals between past reference and predicted blood glucose values is solved remotely to identify personalized calibration parameters. The newly identified parameters are used to initialize the calibration mechanism of the following week.
Results:
The proposed method was evaluated using two sets of clinical data both consisting of 6 weeks of Dexcom G4 Platinum CGM data on 10 adults with T1DM (over 10 000 hours of CGM use), with seven SMBG data points per day measured by each subject in an unsupervised outpatient setting. Updating the calibration parameters using the history of calibration data indicated a positive trend of improving CGM performance.
Conclusions:
Although not statistically significant, the updating framework showed a relative improvement of CGM accuracy compared to the non-updating, static calibration method. The use of information collected for longer periods is expected to improve the performance of the sensor over time.