Related Experiment Videos
Prostate-Specific Membrane Antigen in Low-Grade Fibromatosis
Ramin Akbarian Aghdam1, Masoumeh Hakiminejad, Hamidreza Hashemifard
1From the *Department of Nuclear Medicine, Shohadae Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran; †Department of Radiation Oncology, Vaseie Hospital, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar; and ‡Department of Pathology, Shohadae Tajrish Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical Nuclear Medicine
|October 17, 2017
Summary
Prostate-specific membrane antigen (PSMA) scans can show false positives. This case highlights fibromatosis appearing as a PSMA-avid mass, emphasizing the need for pathological confirmation.
Area of Science:
- Oncology
- Nuclear Medicine
- Pathology
Background:
- Rising prostate-specific antigen (PSA) levels necessitate further investigation.
- Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging is a key diagnostic tool.
- Diagnostic imaging modalities play a crucial role in cancer staging and management.
Observation:
- A 76-year-old man presented with elevated PSA levels.
- Bone scan revealed abnormal soft tissue uptake near the right scapula, suggestive of a mass.
- Gallium-68 (Ga)-PSMA scans were unavailable, and Lutetium-177 (Lu)-PSMA scans were utilized for further assessment.
Findings:
- The Lu-PSMA scan identified a PSMA-avid mass.
- Pathological examination confirmed the mass as low-grade fibromatosis.
- This case represents a false-positive PSMA scan result.
Implications:
- PSMA-avid findings on imaging do not always indicate prostate cancer.
- Pathological examination is essential for definitive diagnosis.
- Careful interpretation of PSMA scans is required, considering potential false positives.