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Patient-reported outcomes in asthma clinical trials
Fulvio Braido1, Ilaria Baiardini1, Giorgio W Canonica2
1Department of Internal Medicine, IRCCS San Martino di Genova University Hospital, Genoa.
Current Opinion in Pulmonary Medicine
|October 17, 2017
Summary
Asthma clinical trials rarely evaluate patient-reported outcomes (PROs), despite a shift towards patient-centered care. Improving PRO assessment is crucial for understanding treatment impact and personalizing medicine.
Area of Science:
- Pulmonology
- Clinical Research
- Patient-Reported Outcomes
Background:
- Healthcare increasingly emphasizes patient-centered approaches.
- Patient perspectives are vital for understanding disease and treatment impact.
Purpose of the Study:
- To review asthma clinical trials published in the last 18 months.
- To evaluate the inclusion and methodology of patient-reported outcomes (PROs) in these trials.
Main Methods:
- Systematic review of peer-reviewed asthma clinical trials.
- Analysis of studies incorporating patient-reported outcomes (PROs).
Main Results:
- Only 20 out of nearly 300 recent asthma trials evaluated PROs.
- None of the PRO evaluations were conducted in real-life settings.
- Significant improvement is needed in applying scientific methods for PRO investigations.
Conclusions:
- Current PRO assessment in asthma clinical trials is insufficient.
- Enhanced systematic approaches are required for rigorous PRO evaluation.
- Recommendations are proposed for PRO assessment, especially in personalized medicine research.