Introduction to Chronobiology
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Updated: Oct 27, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Sandra J Kuhlman1, L Michon Craig2, Jeanne F Duffy3
1Department of Biological Sciences, and Center for the Basis of Neural Cognition Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Abstract:
A diverse range of species, from cyanobacteria to humans, evolved endogenous biological clocks that allow for the anticipation of daily variations in light and temperature. The ability to anticipate regular environmental rhythms promotes optimal performance and survival. Herein we present a brief historical timeline of how circadian concepts and terminology have emerged since the early observation of daily leaf movement in plants made by an astronomer in the 1700s.
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