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Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric Analysis
Alpana A Dongargaonkar1, Jeffrey D Clogston2
1Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA.
Methods in Molecular Biology (Clifton, N.J.)
|October 18, 2017
Summary
Thermogravimetric analysis (TGA) quantifies nanoparticle surface coatings crucial for nanomedicine. This technique also measures residual metal content, ensuring safety and efficacy in therapeutic applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Nanoparticles are integral to nanomedicine and nanotherapeutics.
- Surface coatings on nanoparticles, like metallic ones, enhance dispersion and stability.
- Understanding surface modifications is vital as they influence biological interactions.
Purpose of the Study:
- To describe the Thermogravimetric Analysis (TGA) technique for nanoparticle characterization.
- To detail experimental methods for quantifying nanoparticle surface coatings.
- To explain TGA's utility in determining residual metal content.
Main Methods:
- Thermogravimetric Analysis (TGA) was employed.
- Experiments were conducted under inert atmospheres.
- TGA was used to measure the mass loss corresponding to surface coatings.
Main Results:
- TGA effectively quantifies the amount of surface coating on nanoparticles.
- Running TGA under inert conditions allows for the determination of residual metal content.
- The described methods provide accurate measurements of nanoparticle surface modifications.
Conclusions:
- Thermogravimetric Analysis is a valuable method for characterizing nanoparticle surface coatings.
- The technique is essential for quality control in nanomedicine and nanotherapeutics.
- Accurate measurement of coatings and residual metals ensures nanoparticle safety and performance.