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Related Experiment Videos

Systemic toxicity induced by aggregated layered double hydroxide nanoparticles.

Mina Yan1, Chanzhen Yang1, Binyao Huang1

  • 1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou, China.

International Journal of Nanomedicine
|October 19, 2017
PubMed
Summary

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Naked layered double hydroxide (LDH) nanoparticles cause lung toxicity and death in mice due to aggregation. Lipid membrane coating prevents aggregation, significantly reducing LDH nanoparticle toxicity for safer biomedical applications.

Area of Science:

  • Nanomaterials Science
  • Biomedical Engineering
  • Toxicology

Background:

  • Layered double hydroxide (LDH) nanoparticles show promise for biomedical uses.
  • Systemic toxicity of LDH nanoparticles in vivo is not well understood.
  • Nanoparticle aggregation can influence in vivo toxicity.

Purpose of the Study:

  • To investigate the in vivo systemic toxicity of naked LDH nanoparticles.
  • To examine the impact of nanoparticle aggregation on LDH toxicity.
  • To evaluate the potential of lipid membrane coating to mitigate LDH toxicity.

Main Methods:

  • Intravenous administration of naked and lipid membrane-coated LDH nanoparticles in mice.
  • Monitoring of animal survival rates and tissue distribution.
Keywords:
aggregationerythrocyte aggregationinorganic nanoparticlespulmonary embolismrepeated intravenous injectionsudden death

Related Experiment Videos

  • Histopathological examination of lung tissues for signs of toxicity.

    • Main Results:

    • Naked LDH nanoparticles aggregated upon mixing with saline or erythrocytes.
    • Significant lung accumulation and 0% survival rate observed after repeated injections of naked LDH.
    • Lipid membrane-coated LDH nanoparticles did not aggregate and showed no mortality.

    Conclusions:

    • Repeated intravenous injections of naked LDH nanoparticles are lethal in mice, even at low doses.
    • Aggregation of LDH nanoparticles is a critical factor contributing to their systemic toxicity.
    • Lipid membrane coating is a viable strategy to reduce the toxicity risk of LDH nanoparticles for biomedical applications.