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First Steps towards the Pharmaceutical Development of Ovules Containing Lactobacillus Strains: Viability and
A L Camilletti1,2, F O Ruíz3,4, L M Pascual1
1Area Bacteriología, Departamento de Microbiología e Inmunología, Facultad Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto (UNRC), 5800, Río Cuarto, Córdoba, Argentina.
AAPS Pharmscitech
|October 19, 2017
Summary
This study developed stable vaginal probiotic ovules using Lactobacillus fermentum and Lactobacillus rhamnosus. These formulations maintained probiotic viability and function for 180 days, offering a promising alternative for women
Area of Science:
- Microbiology
- Pharmaceutical Sciences
- Women's Health
Background:
- Limited availability of vaginal probiotic bioproducts in Latin America.
- High cost of conventional treatments for female genital tract infections.
- Need for innovative, cost-effective women's health solutions.
Purpose of the Study:
- To develop and characterize pharmaceutical formulations for vaginal ovules containing Lactobacillus fermentum L23 and Lactobacillus rhamnosus L60.
- To determine the optimal formulation for sustained lactobacilli viability.
- To evaluate the retention of antimicrobial activity and biofilm-producing ability of probiotic strains recovered from ovules.
Main Methods:
- Development and characterization of three pharmaceutical formulations with varying glycerol content.
- Assessment of lactobacilli viability, antimicrobial activity, and biofilm production.
- Long-term storage stability testing at 4°C for 180 days.
Main Results:
- Lactobacilli viability was sustained for 180 days at 4°C, influenced by ovule glycerol content.
- Both Lactobacillus fermentum L23 and Lactobacillus rhamnosus L60 maintained antimicrobial and biofilm-producing capabilities.
- A suitable formulation was identified that preserved probiotic viability and function.
Conclusions:
- Optimized pharmaceutical formulations can ensure long-term viability and functional activity of vaginal probiotics.
- Developed probiotic ovules offer a promising, stable, and effective option for women's health.
- This research presents a viable challenge and opportunity for the pharmaceutical industry in developing novel bioproducts.