Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-induced hypothyroidism.

Leonardo F L Rizzo1, Daniela L Mana1, Héctor A Serra2

  • 1Dirección Médica Química Montpellier SA, Argentina.

Medicina
|October 19, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges in the treatment of hypothyroidism: malabsorption and pseudo-malabsorption of levothyroxine.

Medicina·2025
Same author

Descriptive assessment of 54 cases with complex regional pain syndrome in lower limbs.

Medicina·2023
Same author

Lithium and endocrine dysfunction.

Medicina·2022
Same author

Endocrine dysfunction induced by immune checkpoint inhibitors.

Medicina·2021
Same author

Adrenal axis in critical illness.

Medicina·2021
Same author

Treatment of hypothyroidism in special situations.

Medicina·2021
Same journal

Detection of VIM-3 in oral squamous cell carcinomas: methodological limitations.

Medicina·2026
Same journal

The importance of specific antibodies in VIM-3 research: addressing a key methodological flaw.

Medicina·2026
Same journal

[From the right to be cared for to the duty to care: Legal bases for the implementation of palliative care in Argentina].

Medicina·2026
Same journal

[Surrogacy].

Medicina·2026
Same journal

[The misunderstandings in interpreting the "diagnostic superiority of Artificial Intelligence" and the explainable Artificial Intelligence].

Medicina·2026
Same journal

[Artificial intelligence in medicine: between algorithmic opacity and clinical responsibility].

Medicina·2026
See all related articles

Drug-induced thyroid dysfunction, primarily hypothyroidism, is a growing concern. Evaluating thyroid function before prescribing certain medications is crucial to prevent adverse effects and manage treatment interactions.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Internal Medicine

Background:

  • The thyroid axis is susceptible to drug interactions, with an increasing number of medications affecting thyroid function.
  • Drug-induced thyroid dysfunction, predominantly hypothyroidism, is a significant clinical issue.
  • Understanding these interactions is vital for patient safety and effective treatment.

Purpose of the Study:

  • To review the mechanisms of drug-induced thyroid dysfunction, including primary and central hypothyroidism.
  • To highlight drugs that interfere with levothyroxine treatment.
  • To emphasize the importance of pre-prescription thyroid function evaluation.

Main Methods:

  • Literature review of drug-induced thyroid dysfunction.
  • Analysis of mechanisms: hormone synthesis inhibition, immune responses, receptor blockade.
Keywords:
drugshypothyroidismthyroid

Related Experiment Videos

  • Identification of drugs affecting thyroid hormone absorption, transport, and metabolism.

    • Main Results:

    • Primary hypothyroidism mechanisms include synthesis inhibition, immune reactions (interferon, cytokines), and drug-induced thyroiditis (tyrosine kinase inhibitors, VEGF inhibitors).
    • Central hypothyroidism can result from TSH inhibition (bexarotene, corticosteroids) or immunological effects (anti-CTLA4, anti-PD-1 antibodies).
    • Levothyroxine efficacy can be compromised by drugs affecting its absorption, transport, or metabolism.

    Conclusions:

    • Pre-prescription thyroid function assessment is strongly recommended for drugs like amiodarone, lithium, interferon, and new biological therapies.
    • Awareness of drug-endocrine interactions, particularly with thyroid function, is essential for clinicians.
    • Proactive monitoring and management are necessary to mitigate risks associated with drug-induced thyroid dysfunction.