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Analytical problems encountered during high-performance liquid chromatographic separation and coulometric detection
S L Perkins1, B Tattrie, P M Johnson
1Division of Biochemistry, Ottawa Civic Hospital, Ontario, Canada.
Therapeutic Drug Monitoring
|January 1, 1988
Abstract:
Good clinical control of hypertension is achieved with low doses of the potent beta-blocker bopindolol. Pharmacokinetic evaluations therefore require an analytical technique of high sensitivity. Analysis of plasma by high-performance liquid chromatography (HPLC) using electrochemical detection provides this sensitivity. This article describes the development of an analytical procedure and presents a reversed-phase HPLC method with coulometric detection suitable for plasma analyses during pharmacokinetic investigations of bopindolol therapy.