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Isolation of Cerebrospinal Fluid from Rodent Embryos for use with Dissected Cerebral Cortical Explants

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Central sulcus development in early childhood.

Niharika Gajawelli, Sean Deoni, Holly Dirks

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|October 25, 2017

Summary

Brain development in early childhood is key to understanding neurological disorders. This study maps changes in the Central Sulcus (CS) from ages 1-3, revealing its connection to mouth and tongue development.

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Area of Science:

Neuroscience
Developmental Biology
Pediatric Imaging

Background:

Early brain development is crucial for understanding neurological disorders.
The brain reaches 95% of its adult volume by age 6.
A normative developmental atlas is needed for neurological disease progression studies.

Purpose of the Study:

To investigate changes in the Central Sulcus (CS) in early childhood (1-3 years).
To parameterize the CS and correlate its development with other brain regions.
To contribute to a normative atlas for pediatric brain development.

Main Methods:

Utilized high-resolution magnetic resonance imaging (MRI) for pediatric subjects aged 1-3 years.
Performed detailed parameterization of the Central Sulcus (CS).
Analyzed structural changes in the CS during early development.

Main Results:

Observed significant changes in the Central Sulcus (CS) between ages 1 and 3.
Found a correlation between CS development and the maturation of mouth and tongue regions.
Established preliminary normative data for CS development in toddlers.

Conclusions:

The Central Sulcus (CS) undergoes dynamic changes in early childhood.
CS development is linked to the maturation of sensorimotor areas for the mouth and tongue.
This research provides foundational data for understanding typical and atypical brain development.