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Neurotransmitters and intraocular pressure.
Fundamental & Clinical Pharmacology
|January 1, 1988
Summary
The ocular autonomic nervous system significantly influences intraocular pressure (IOP) regulation. Future glaucoma treatments may target dopaminergic agonists, prostaglandins, and cannabinoids.
Area of Science:
- Ocular pharmacology
- Autonomic nervous system
- Intraocular pressure regulation
Background:
- The ocular autonomic nervous system plays a crucial role in regulating intraocular pressure (IOP).
- High densities of beta-2 and alpha-2 adrenergic receptors are present on ciliary processes and iris epithelium.
Purpose of the Study:
- To discuss the pharmacological activation and blockade of these receptors.
- To explore the complex roles of various ocular neurotransmitters in IOP modulation.
- To identify potential targets for future IOP-lowering drugs.
Main Methods:
- Pharmacological studies
- Autohistoradiographic studies
Main Results:
- Pharmacological activation/blockade effects on IOP are discussed.
- Dopamine agonists and antagonists exhibit paradoxical effects on IOP.
- Ocular muscarinic receptors' pharmacology is not well-documented.
Conclusions:
- Numerous neurotransmitters can modulate IOP.
- Future drug development may focus on dopaminergic agonists, cAMP-stimulators (e.g., forskolin), prostaglandins, and cannabinoids for IOP management.