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A current produced due to the redox reactions of the analyte at the working and auxiliary electrodes is called a faradaic current. The reaction can be divided into two types. The current generated due to the reduction of the analyte is called cathodic current, and it carries a positive charge. In contrast, the current produced by analyte oxidation is known as an anodic current, and it has a negative charge. The applied potential at the working electrode determines the faradaic current flow, and...

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Author Spotlight: Studying Biomechanics of Circulating Cells by Modulating Their Electrodeformation Behavior

Author Spotlight: Studying Biomechanics of Circulating Cells by Modulating Their Electrodeformation Behavior

Published on: October 13, 2023

Determination of Red Blood Cell fatigue using electrodeformation.

A Amirouche, M Faivre, J F Chateaux

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|October 25, 2017

Summary

This study introduces electrodeformation to assess red blood cell (RBC) fatigue by analyzing their relaxation time after mechanical stress. Optimized parameters allow for effective monitoring of RBC fatigue in circulation.

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Area of Science:

Biophysics
Cellular Mechanics
Hematology

Background:

Red blood cells (RBCs) undergo mechanical stress during circulation.
Evaluating RBC fatigue is crucial for understanding various health conditions.
Existing methods for assessing RBC mechanical properties have limitations.

Purpose of the Study:

To introduce electrodeformation (ED) as a novel method for evaluating human RBC fatigue.
To model the mechanical stress experienced by RBCs in blood circulation.
To establish RBC relaxation time as a fatigue marker.

Main Methods:

Utilized dielectrophoresis (DEP) forces to induce controlled elongation and relaxation cycles in RBCs.
Investigated the influence of external medium viscosity, voltage amplitude, solicitation duration, number of solicitations, and resting time on RBC mechanical response.
Analyzed RBC deformation index (D) and relaxation time (τ) to assess fatigue.

Main Results:

Determined the dependency of RBC mechanical response on key experimental parameters (viscosity, voltage, duration, number, and rest time).
Established a correlation between ED parameters and RBC fatigue.
Optimized experimental conditions for sensitive monitoring of RBC fatigue.

Conclusions:

Electrodeformation (ED) provides a viable new strategy for evaluating human red blood cell (RBC) fatigue.
RBC relaxation time is a reliable indicator of fatigue under ED.
Optimized ED parameters enable effective monitoring of RBC fatigue, relevant for hematological studies.