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Updated: Feb 20, 2026

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats
Published on: September 27, 2017
Involvement of Microflora Metabolites in Up-Regulation of Electrical Activity in Rat Small Intestine
N S Tropskaya1, E A Kislyakova2, T S Popova2
1N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health, Moscow, Russia. ntropskaya@mail.ru.
Abstract:
The study examined implication of tributyrin, a metabolic precursor in small intestinal microflora, in stimulation of electrical activity of duodenum and jejunum. Enteral administration of tributyrin enhanced electrical activity of both examined structures in small intestine with elimination of the rest periods. The stimulatory effect was manifested in a prolongation of the periods of irregular activity. The up-regulating effects of tributyrin on electrical activity in upper segments of small intestine are mediated via the cholecystokinin receptors being also associated with activation of cholinergic and blockade of nitrinergic signal transduction pathways.
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