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Related Experiment Video

Updated: Feb 20, 2026

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Ocular features of multiple system atrophy.

Maria D Garcia1, Jose S Pulido2, Elizabeth A Coon3

  • 1Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|October 26, 2017
PubMed
Summary
This summary is machine-generated.

Ocular manifestations like dry eye and abnormal eye movements are common in multiple system atrophy (MSA). These eye findings in MSA patients indicate a poorer prognosis and shorter lifespan, necessitating regular neuro-ophthalmologic exams.

Keywords:
Cerebellar dysfunctionDegenerationLife expectancyMultiple system atrophyOcular findingsParkinsonismVision

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Area of Science:

  • Neuro-ophthalmology
  • Neurodegenerative Diseases

Background:

  • Multiple system atrophy (MSA) is a rare neurodegenerative disorder with poorly understood ophthalmologic features.
  • Ocular manifestations in MSA can impact patient prognosis and require further investigation.

Purpose of the Study:

  • To investigate the prevalence and types of ocular abnormalities in patients with multiple system atrophy (MSA).
  • To determine the association between ocular findings and prognosis in MSA patients.

Main Methods:

  • Retrospective case series of 39 confirmed MSA patients at Mayo Clinic between 2005 and 2014.
  • Review of medical records and eye examination findings for ocular abnormalities potentially related to MSA.

Main Results:

  • Ocular findings were present in 64% of MSA patients, most commonly dry eye, conjugate eye movement abnormalities (33%), and ocular misalignment (18%).
  • Conjugate eye movement abnormalities and ocular misalignment were more frequent in MSA with cerebellar features (MSA-C).
  • Patients with ocular findings (excluding dry eye) had a significantly shorter lifespan.

Conclusions:

  • Conjugate eye movement abnormalities and ocular misalignment are common in MSA.
  • Bilateral optic atrophy and cicatricial pemphigoid may be linked to MSA.
  • Ocular manifestations in MSA are associated with a poorer prognosis and shorter lifespan, underscoring the need for comprehensive neuro-ophthalmologic evaluations.