Computational study on neuronal activities arising in the pre-Bötzinger complex

Experimental investigations have shown that the pre-Bötzinger complex (pre-BötC) within the mammalian brainstem generates the inspiratory phase of respiratory rhythm. Based on a single-compartment model of a pre-BötC inspiratory neuron, we, in this paper, use semi-analytical, numerical as well as fast-slow dynamical methods to investigate the effects of sodium conductance ([Formula: see text]) and potassium conductance ([Formula: see text]) on the firing activities of pre-BötC and try to reveal the dynamical mechanisms behind them. We show how [Formula: see text] and [Formula: see text] affect the bifurcations of the fast-subsystem and how the the firing patterns of pre-BötC transit according to the bifurcations.