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Related Experiment Video

Updated: Feb 20, 2026

Control of Eating Behavior Using a Novel Feedback System
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Obesity, Appetite, and the Prefrontal Cortex.

Marci E Gluck1, Pooja Viswanath2, Emma J Stinson2

  • 1Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541, Phoenix, AZ, 85016, USA. gmarci@niddk.nih.gov.

Current Obesity Reports
|October 27, 2017
PubMed
Summary
This summary is machine-generated.

Obesity is a growing global health concern. Research suggests the prefrontal cortex (PFC), specifically the left dorsolateral PFC, plays a key role in appetite control and may be a target for weight loss interventions.

Keywords:
Dorsolateral prefrontal cortexExecutive functionFood intakeNeuroimagingNeuromodulationWeight loss

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Area of Science:

  • Neuroscience
  • Obesity Research
  • Cognitive Science

Background:

  • Obesity is a complex, growing global health issue influenced by various factors affecting food intake.
  • The prefrontal cortex (PFC) is crucial for executive functions, regulating reward pathways, and inhibiting impulsive actions.

Purpose of the Study:

  • To explore the role of the prefrontal cortex (PFC) in appetite regulation.
  • To understand how PFC function relates to obesity etiology and potential weight loss strategies.

Main Methods:

  • Review of neuroimaging studies examining brain activation patterns.
  • Focus on the dorsolateral prefrontal cortex (DLPFC) and its association with appetite and executive control.

Main Results:

  • Neuroimaging reveals reduced left dorsolateral PFC (DLPFC) activation in obese individuals compared to lean individuals.
  • The DLPFC is identified as a critical area for appetitive control, food cravings, and executive functioning.

Conclusions:

  • The DLPFC is a potential therapeutic target for obesity treatment.
  • Further research is necessary to elucidate the obesity-appetite-DLPFC relationship and validate new treatments.