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Updated: Feb 20, 2026

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
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[PRIMARY AND SECONDARY HYPERPARATHYROIDISM PRESENTING AS BROWN TUMOR]
Avraham Toeg1, Victoria Yaffe-Gartsbein1, Omri Emodi2
1The Department of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center, Poriya, Israel.
Harefuah
|October 27, 2017
Summary
Brown tumors, a rare complication of hyperparathyroidism (HPT), can affect the jaw. This study details two cases, one in the maxilla and one in the mandible, discussing diagnosis and management.
Area of Science:
- Endocrinology
- Oral Pathology
- Oncology
Background:
- Hyperparathyroidism (HPT) can cause osteolytic lesions with giant granulomas, termed brown tumors.
- Brown tumors are an end-stage complication of HPT, typically affecting the mandible, clavicles, ribs, and pelvis.
- Maxillary brown tumor involvement is exceptionally rare.
Observation:
- Two distinct cases of brown tumors are presented.
- Case 1: Primary HPT with maxillary brown tumor.
- Case 2: Secondary HPT with mandibular brown tumor.
Findings:
- The study highlights the differential diagnosis and workup for jaw lesions presenting as brown tumors.
- Management strategies for these rare oral manifestations of HPT are discussed.
Implications:
- This research expands understanding of rare HPT complications in the maxillofacial region.
- It provides valuable insights for clinicians managing patients with HPT and jaw lesions.
- Early recognition and appropriate management are crucial for favorable patient outcomes.
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