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Fully Artificial Exosomes: Towards New Theranostic Biomaterials
Pablo García-Manrique1, Gemma Gutiérrez2, Maria Carmen Blanco-López3
1Department of Chemical and Environmental Engineering, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain; Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.
Trends in Biotechnology
|October 28, 2017
Summary
Artificial exosomes, or biomimetic particles, are emerging as therapeutic biomaterials. This review covers their production, applications, and limitations in bionanotechnology.
Area of Science:
- Bionanotechnology
- Biomaterials Science
- Nanomedicine
Background:
- Extracellular vesicles (EVs) have therapeutic potential but face limitations in biology and applications.
- Artificial exosomes offer a biomimetic alternative to natural EVs.
- Bionanotechnology enables the creation of these advanced therapeutic particles.
Purpose of the Study:
- To review current preparation techniques for artificial exosomes.
- To explore the current and future applications of artificial exosomes.
- To identify the limitations of artificial exosome technology.
Main Methods:
- Literature review of bionanotechnology approaches for artificial exosome production.
- Analysis of studies exploring the applications of artificial exosomes.
- Discussion of current challenges and future directions in the field.
Main Results:
- Several bionanotechnology routes exist for producing artificial exosomes.
- Artificial exosomes show promise in various therapeutic applications.
- Current limitations include scalability, characterization, and in vivo behavior.
Conclusions:
- Artificial exosomes represent a promising class of therapeutic biomaterials.
- Further research is needed to overcome current limitations for clinical translation.
- Bionanotechnology advancements are key to unlocking the full potential of artificial exosomes.
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