Related Experiment Video
Updated: Aug 13, 2026
Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
Published on: February 4, 2016
[Neuromodulation can be effective in patients with medically unexplained symptoms]
Background:
Neuromodulation may influence abnormal brain activation patterns in medically unexplained symptoms (MUS).
Aim:
To assess the importance and direction of future studies on patients with MUS.
Method:
We describe the results of the first studies on patients with functional neurological symptom disorder (fNSD) and chronic pain.
Results:
Clinically relevant improvements in the health condition of a substantial number of patients with fnsd have been reported. Randomised clinical trials (RCTs) show significant improvements in patients who have received neuromodulation for chronic pain.
Conclusion:
In our view it is important to perform placebo-controlled RCTs in order to test the therapeutic effect of neuromodulation on patients with MUS. We need to find out more about the involuntary mechanisms and the possible role of the brain in MUS and chronic pain. Neuroimaging would be helpful in this respect.
Related Concept Videos
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...