Visceral adiposity and renal function: an observational study from SPECT-China.

Area of Science:

• Nephrology
• Metabolic Syndrome
• Public Health

Background:

• Lipid accumulation product (LAP) is a novel index for visceral adiposity, calculated using waist circumference and triglycerides.
• Limited research exists on the association between LAP and estimated glomerular filtration rate (eGFR).
• This study investigates LAP's relationship with declined renal function and its predictive superiority over other obesity indices.

Purpose of the Study:

• To explore the association between LAP and declined renal function (eGFR < 60 mL/min/1.73m²).
• To determine if LAP is superior to other obesity indices in predicting kidney impairment.

Main Methods:

• A cross-sectional study involving 10,012 participants from 22 sites in East China.
• LAP was calculated using the formula: (WC-65) x TG for males and (WC-58) x TG for females.
• Statistical analyses adjusted for age, sex, smoking, drinking, diabetes, and hypertension.

Main Results:

• 4.7% of participants had declined renal function and higher LAP quartiles.
• LAP showed a strong association with eGFR levels (Beta: -0.073, P < 0.001) and declined renal function (P < 0.001).
• The highest LAP quartile increased renal dysfunction risk 2.32-fold (OR: 2.32, 95% CI: 1.52-3.53).
• LAP demonstrated the largest area under the curve (AUC ROC: 0.644) in predicting kidney impairment compared to other obesity indices.

Conclusions:

• LAP is strongly associated with declined renal function in the Chinese population.
• LAP can serve as a valuable marker for predicting the risk of renal dysfunction.