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Red Wine, Resveratrol and Atrial Fibrillation.

Laura Siga Stephan1, Eduardo Dytz Almeida2, Melissa Medeiros Markoski3,4

  • 1Postgraduate Program in Health Sciences: Cardiology, Institute of Cardiology/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 370, Porto Alegre RS 90620-001, Brazil. emaildalaura@gmail.com.

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While excessive alcohol increases atrial fibrillation (AF) risk, light/moderate intake and red wine

Keywords:
atrial fibrillationtrans-resveratrolwine

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Area of Science:

  • Cardiology
  • Pharmacology
  • Nutritional Science

Background:

  • Atrial fibrillation (AF) is a prevalent cardiac arrhythmia linked to higher mortality.
  • Excessive alcohol consumption is a known risk factor for AF, but the effects of light to moderate drinking remain unclear.
  • Red wine contains resveratrol, a polyphenol with potential antiarrhythmic properties.

Purpose of the Study:

  • To review potential benefits of red wine and resveratrol in atrial fibrillation.
  • To examine human studies on chronic red wine consumption, resveratrol, and AF risk.

Main Methods:

  • Literature review of existing studies.
  • Analysis of human trials and observational data.

Main Results:

  • No clinical trials confirm improved outcomes from resveratrol supplementation.
  • No observational studies support a reduced AF risk with light or moderate alcohol intake.
  • Low-dose red wine may acutely affect cardiac repolarization and conduction.

Conclusions:

  • Evidence for beneficial effects of red wine or resveratrol on AF in humans is currently lacking.
  • Further research is needed to clarify the relationship between moderate alcohol consumption, resveratrol, and atrial fibrillation.