Genomicus 2018: karyotype evolutionary trees and on-the-fly synteny computing.

Area of Science:

• Comparative genomics
• Bioinformatics
• Evolutionary biology

Background:

• The Genomicus web server has provided comparative genomic analyses since 2010.
• It covers four major phyla: Vertebrates, Plants, Fungi, and non-vertebrate Metazoans.
• Genomicus integrates genomic information of extant species with ancestral gene content and order within an evolutionary framework.

Purpose of the Study:

• To introduce recent advancements and new visualization tools in the Genomicus web server, specifically for vertebrate genomics.
• To enhance the comparative genomic analysis capabilities for researchers.
• To facilitate the study of genome evolution through improved visualization.

Main Methods:

• Implementation of new analysis and visualization modules within the Genomicus web server.
• Development of Multi-KaryotypeView for comparing karyotype structures across evolutionary pathways.
• Integration of PhylDiagView for computing and visualizing synteny blocks between any two genomes.

Main Results:

• Genomicus now offers advanced tools for comparative genomic analysis.
• Multi-KaryotypeView allows for the visualization of karyotype evolution.
• PhylDiagView enables detailed synteny block analysis between diverse genomes.

Conclusions:

• The updated Genomicus web server provides powerful new tools for evolutionary genomic research.
• Enhanced visualization capabilities facilitate the understanding of genome structure and evolution.
• Genomicus continues to be a valuable resource for comparative genomics across multiple phyla.