Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamics of Heparin Translocations Through Solid-State Nanopores.

Electrophoresis·2026
Same author

Catch-and-display immunoassay for digital biomarker detection.

Nanoscale horizons·2026
Same author

Nanomembrane-based microfluidic platform with embedded electrical pressure transducer for on-chip nanoparticle quantification.

Lab on a chip·2026
Same author

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugs.

bioRxiv : the preprint server for biology·2026
Same author

Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells.

Lab on a chip·2026
Same author

Modular Integration of Impedance Sensing for Real-Time Assessment of Barrier Integrity.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Feb 19, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K

DNA Translocations through Nanopores under Nanoscale Preconfinement.

Kyle Briggs1, Gregory Madejski2, Martin Magill3

  • 1Department of Physics, University of Ottawa , Ottawa, Ontario K1N 6N5, Canada.

Nano Letters
|November 1, 2017
PubMed
Summary

Nanoscale preconfinement using nanofilters dramatically reduces DNA passage time variation in solid-state nanopores. This innovation improves DNA length separation and data collection rates for sequencing and mapping applications.

Keywords:
DNANanoporeentropynanoconfinementnanofabricationnanotechnology

More Related Videos

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

12.2K
Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

12.8K

Related Experiment Videos

Last Updated: Feb 19, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

12.2K
Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

12.8K

Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Solid-state nanopores are crucial for DNA analysis.
  • Variations in DNA passage speed cause data inaccuracies.
  • Controlling molecular translocation is key for advanced sensing.

Purpose of the Study:

  • To minimize passage time variation for DNA translocation through solid-state nanopores.
  • To enhance the reliability and efficiency of nanopore-based DNA analysis.
  • To investigate the role of nanoscale preconfinement in molecular transport.

Main Methods:

  • Fabrication of integrated nanofilter/nanopore devices using silicon nitride membranes.
  • Experimental measurements of DNA passage times through the devices.
  • Computational simulations to analyze molecular dynamics and transport phenomena.

Main Results:

  • Nanoscale preconfinement eliminated pore size dependence of DNA passage time distributions.
  • A global minimum in the coefficient of variation for passage time was observed.
  • Narrower passage time distributions enabled pore-size-independent DNA length separation.
  • Suppression of folded translocations ensured single-file DNA passage.

Conclusions:

  • Integrated nanofilters effectively control DNA translocation dynamics in solid-state nanopores.
  • The method significantly enhances data acquisition rates for nanopore sensing.
  • This approach offers practical advantages for DNA sequencing, genomic mapping, and target detection.