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Published on: June 2, 2015
A Test in Context: D-Dimer.
Jeffrey I Weitz1, James C Fredenburgh2, John W Eikelboom2
1Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
D-dimer, a marker of blood clot breakdown, is crucial for diagnosing venous thromboembolism (VTE) and guiding treatment. Its measurement aids in managing coagulation disorders and identifying patients at high risk for VTE.
Area of Science:
- Hematology
- Clinical Chemistry
Background:
- D-dimer is a fibrin degradation product reflecting coagulation and fibrinolysis.
- It is routinely used in diagnosing venous thromboembolism (VTE).
Purpose of the Study:
- To review D-dimer generation, detection assays, and its clinical applications.
- To discuss the role of D-dimer in guiding therapy for various conditions.
Main Methods:
- Literature review of studies on D-dimer.
- Analysis of D-dimer generation and assays.
- Discussion of clinical utility in VTE, disseminated intravascular coagulation, and risk stratification.
Main Results:
- D-dimer is a key indicator of coagulation and fibrinolysis activation.
- It is essential for VTE diagnosis and management.
- D-dimer aids in assessing anticoagulation duration and identifying high-risk patients.
Conclusions:
- D-dimer quantification is vital for clinical decision-making.
- Its role extends to diagnosing and monitoring coagulopathies.
- D-dimer measurement guides therapeutic strategies in thrombotic disorders.
