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Histological coherent Raman imaging: a prognostic review
Marcus T Cicerone1, Charles H Camp
1100 Bureau Drive, Mail Stop 8543, Gaithersburg, MD 20899, USA. cicerone@nist.gov.
The Analyst
|November 4, 2017
Summary
Histopathology is transitioning from art to science. Coherent Raman imaging (CRI) offers label-free, molecule-specific contrast, aiding this transformation in cancer diagnosis.
Area of Science:
- Histopathology
- Medical Imaging
- Biophysics
Background:
- Histopathology is crucial for disease diagnosis, particularly in solid cancers.
- Current histopathology relies on subjective interpretation, necessitating a shift towards objective, quantitative methods.
- Modernization efforts aim to enhance diagnostic accuracy and reproducibility.
Purpose of the Study:
- To survey key themes in histopathology modernization.
- To review the applications of Coherent Raman Imaging (CRI) in histopathology.
- To discuss the potential of CRI in transforming quantitative histopathology.
Main Methods:
- Literature review of histopathology modernization.
- Survey of existing Coherent Raman Imaging (CRI) applications in histopathology.
- Analysis of CRI's characteristics for quantitative histopathology.
Main Results:
- Coherent Raman Imaging (CRI) provides label-free, sub-cellular resolution imaging.
- CRI offers molecule-specific contrast, enabling quantitative analysis.
- CRI's attributes align with the requirements for objective histopathological assessment.
Conclusions:
- Coherent Raman Imaging (CRI) is a promising technology for quantitative histopathology.
- CRI can significantly contribute to the ongoing transformation of histopathology into an objective science.
- Further integration of CRI is expected to enhance diagnostic capabilities in various diseases, including cancer.
