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Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
Published on: May 6, 2015
Intermediate adenovirus strains of subgenus D occur in extensive variety
1Abteilung für Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universitätskliniken, Homburg/Saar, Federal Republic of Germany.
Abstract:
Eight intermediate adenovirus strains of seven serotypes, some of them related in their neutralizing or hemagglutinating antigens to new candidate serotypes, are presented in their serological properties and DNA fragment patterns with four endonucleases (BglII, BstEII, HindIII, SmaI). For characterization and strain comparison, an intensive serological identification is more meaningful than DNA restriction analysis. The intermediate strains were related in neutralization to types 28, 33, 37, 38, 44, or 46, in hemagglutination-inhibition to types 9, 13, 30, 45, or the hemagglutinin variant Hy.
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