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Updated: Feb 19, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones
Rick C Betori1, Eric R Miller1, Karl A Scheidt1,2
1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Abstract:
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability.
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