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Pristinamycin-induced arthralgia and myalgia: Analysis of the French Pharmacovigilance Database
M Denis Prevot1, E M Thillard1, J Walther2
1Centre régional de pharmacovigilance de Lille, faculté de médecine, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France.
Introduction:
Pristinamycin is an antibiotic of the streptogramin family; few adverse effects of this drug are reported, only cutaneous and digestive ones. Arthralgia and myalgia may however be observed although not mentioned in the summary of product characteristics.
Objective:
Description and analysis of cases of pristinamycin-induced arthralgia and/or myalgia registered in the French database of pharmacovigilance.
Method:
We carried out a targeted search of the database, selecting case patients presenting with arthralgia and muscle pain and excluding those associated with sensitivities or allergies to pristinamycin.
Results:
We retrieved 15 case patients of pristinamycin-induced arthralgia and myalgia. Pristinamycin was the only potentially incriminated drug for seven case patients.
Conclusion:
Although not serious, this adverse effect deserves to be better known by physicians to optimize therapeutic management.
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