Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform.

Frontiers in bioengineering and biotechnology·2024

Same author

Decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic.

Bioactive materials·2022

Same author

Strength of interference screw fixation of meniscus prosthesis matches native meniscus attachments.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2021

Same author

3D porous Ti6Al4V-beta-tricalcium phosphate scaffolds directly fabricated by additive manufacturing.

Acta biomaterialia·2021

Same author

Injectable, self-healing mesoporous silica nanocomposite hydrogels with improved mechanical properties.

Nanoscale·2021

Same author

Mesoporous bioactive glass composition effects on degradation and bioactivity.

Bioactive materials·2021

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study

D Barata¹, E Provaggi, C van Blitterswijk

¹Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Overijssel, The Netherlands.

|November 9, 2017

Summary

This study presents a novel microfluidic device for cell-material interaction studies. The device, made from polylactic acid (PLA), allows for controlled cell culture and surface microstructuring to investigate cell behavior on biomaterials.

More Related Videos

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

Published on: August 30, 2007

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Related Experiment Videos

Last Updated: Feb 19, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

Published on: August 30, 2007

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

Area of Science:

Biomaterials Science
Cell Biology
Microfluidics

Background:

Microfluidic platforms enhance in vitro cell-based assays by mimicking physiological conditions.
Integrating biomaterials into microfluidic devices offers insights into cell-material interactions.

Purpose of the Study:

To develop a microfluidic device for studying cell-material interactions.
To investigate the effect of microstructured surfaces on cell behavior.

Main Methods:

Fabrication of a polylactic acid (PLA) microfluidic device using photolithography, two-photon polymerization, and hot embossing.
Cell culture under perfusion and diffusion fluidic regimes.
Microstructuring of the cell culture chamber surface with defined geometrical features.

Main Results:

The microfluidic device enabled controlled cell culture under various fluidic conditions.
Surface microtopography, including feature height and wall properties, influenced human MG63 osteosarcoma cell adhesion, morphology, and distribution.
Cell spreading and distribution were significantly affected by topographical features.

Conclusions:

The developed microfluidic platform is a valuable tool for studying cell-biomaterial interactions.
Controlled fluidic regimes and surface microstructuring are crucial for understanding cell behavior in microenvironments.
This proof-of-concept study demonstrates the utility of microfluidics for biomaterial research.