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Four new monacolin analogs from Monascus purpureus-fermented rice
Bo Zhang1, Tian-Xi Liu2, A-Li Wang1
1a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
Abstract:
Four new monacolin analogs, monacolin T (1), monacolin U (2) 6a-O-methyl-4,6-dihydromonacolin L (3), and 6a-O-ethyl-4,6-dihydromonacolin L (4) were isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures were determined by a combination of 1D, 2D NMR experiments (1H-1HCOSY, HSQC, HMBC, and ROESY), and mass spectrometry. In vitro cytotoxic assay, all compounds were inactive at the concentration of 10 µM.
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