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Eating Disorders, Autoimmune, and Autoinflammatory Disease.
Stephanie Zerwas1, Janne Tidselbak Larsen2,3, Liselotte Petersen2,3
1Departments of Psychiatry and.
Pediatrics
|November 11, 2017
Summary
Children and adolescents with autoimmune or autoinflammatory diseases face a higher risk of developing eating disorders. A family history of these immune conditions also increases the likelihood of eating disorders in offspring.
Area of Science:
- Pediatric Health
- Immunology
- Psychiatry
Background:
- Identifying eating disorder risk factors is crucial for early detection and understanding etiology.
- Autoimmune and autoinflammatory diseases are increasingly recognized for their systemic effects.
Purpose of the Study:
- To investigate the association between autoimmune/autoinflammatory diseases and eating disorders in children and adolescents.
- To examine if a family history of these diseases influences eating disorder risk.
Main Methods:
- A large, nationwide, population-based cohort study in Denmark.
- Included 930,977 individuals born between 1989-2006, with data up to 2012.
- Utilized Danish medical registers and employed Cox proportional hazards and logistic regression models.
Main Results:
- Children and adolescents with autoimmune or autoinflammatory diseases had significantly higher hazards for anorexia nervosa (36%), bulimia nervosa (73%), and eating disorder not otherwise specified (72%).
- Associations were particularly pronounced in boys.
- Parental history of autoimmune/autoinflammatory diseases correlated with increased odds for all types of eating disorders.
Conclusions:
- Autoimmune and autoinflammatory diseases are linked to an elevated risk of eating disorders in pediatric populations.
- Investigating immune system involvement in eating disorder pathogenesis may reveal new therapeutic avenues.
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