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Published on: May 29, 2017
A chiral template-driven synthesis of a 3'-deoxy-3'-18F-fluorothymidine precursor
Papiya Dey1, K S Ajish Kumar2, Anubha Sharma1
1Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai -400094, India.
Abstract:
An asymmetric synthesis of a 3'-deoxy-3'-18F-fluorothymidine (18F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the 18F-FLT precursors wherein the expensive starting material, thymidine was used.
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