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[Vascular dysfunction in obstructive sleep apnoea: Implication of microparticules]

W Trzepizur1, P Priou1, N Meslier1

  • 1Département de pneumologie, CHU d'Angers, 4, rue Larrey, 49100 Angers, France; Inserm UMR 1063, stress oxydant et pathologies métaboliques (SOPAM), université d'Angers, université Bretagne-Loire, 49100 Angers, France.

Revue De Pneumologie Clinique
|November 12, 2017
PubMed

Insights

Obstructive sleep apnea (OSA) increases cardiovascular risks. This study reviews how microparticles (MPs) released during OSA may drive atherosclerosis and vascular dysfunction.

Area of Science:

  • Cardiovascular Science
  • Sleep Medicine
  • Cell Biology

Background:

  • Obstructive sleep apnea (OSA) is linked to cardiovascular diseases like heart attack and stroke.
  • OSA exacerbates risk factors such as diabetes and hypertension.
  • Microparticles (MPs), released from blood cells, are implicated in atherosclerosis.

Purpose of the Study:

  • To review the characteristics of MPs in OSA.
  • To explore the role of MPs in the atherogenic process associated with OSA.

Main Methods:

  • Review of case-control studies on MPs in OSA patients.
  • Analysis of research on the effects of OSA-derived MPs in animal models.

Main Results:

  • OSA is associated with elevated levels of platelet-, endothelial-, and leukocyte-derived MPs.
  • MPs from OSA patients can induce vascular inflammation and endothelial dysfunction in mice.

Conclusions:

  • MPs are a significant factor in the atherogenic process in OSA.
  • Understanding MP characteristics in OSA is crucial for cardiovascular risk management.
Keywords:
AtherogenesisDysfonction endothélialeMicroparticlesMicroparticulesObstructive sleep apneaSyndrome d’apnées hypopnées du sommeil

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