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[Vascular dysfunction in obstructive sleep apnoea: Implication of microparticules].
W Trzepizur1, P Priou1, N Meslier1
1Département de pneumologie, CHU d'Angers, 4, rue Larrey, 49100 Angers, France; Inserm UMR 1063, stress oxydant et pathologies métaboliques (SOPAM), université d'Angers, université Bretagne-Loire, 49100 Angers, France.
Obstructive sleep apnea (OSA) increases cardiovascular risks. This study reviews how microparticles (MPs) released during OSA may drive atherosclerosis and vascular dysfunction.
Area of Science:
- Cardiovascular Science
- Sleep Medicine
- Cell Biology
Background:
- Obstructive sleep apnea (OSA) is linked to cardiovascular diseases like heart attack and stroke.
- OSA exacerbates risk factors such as diabetes and hypertension.
- Microparticles (MPs), released from blood cells, are implicated in atherosclerosis.
Purpose of the Study:
- To review the characteristics of MPs in OSA.
- To explore the role of MPs in the atherogenic process associated with OSA.
Main Methods:
- Review of case-control studies on MPs in OSA patients.
- Analysis of research on the effects of OSA-derived MPs in animal models.
Main Results:
- OSA is associated with elevated levels of platelet-, endothelial-, and leukocyte-derived MPs.
- MPs from OSA patients can induce vascular inflammation and endothelial dysfunction in mice.
Conclusions:
- MPs are a significant factor in the atherogenic process in OSA.
- Understanding MP characteristics in OSA is crucial for cardiovascular risk management.
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