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Updated: Feb 19, 2026
09:01
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
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Inflammation and Colorectal Cancer
Apple G Long1, Emma T Lundsmith2, Kathryn E Hamilton1
1Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Current Colorectal Cancer Reports
|November 14, 2017
Summary
Inflammation plays a key role in colorectal cancer (CRC) development. This review explores how inflammatory signaling pathways in murine models and 3D cultures offer new insights into CRC biomarkers and therapies.
Area of Science:
- Oncology
- Immunology
- Gastroenterology
Background:
- Colorectal cancer (CRC) is a leading cause of cancer death in the US.
- Inflammation is a critical factor in CRC development, linked to both IBD and sporadic forms.
- Understanding inflammation's role is crucial for advancing CRC research.
Purpose of the Study:
- To review recent advances in understanding inflammatory signaling pathways in CRC using murine models.
- To explore the contribution of inflammation to sporadic CRC.
- To highlight new research avenues for CRC biomarkers and therapies.
Main Methods:
- Utilizing murine models to study inflammatory signaling in CRC.
- Examining three-dimensional enteroid/colonoid/tumoroid cultures.
- Investigating immune-epithelial interactions in CRC models.
Main Results:
- Advances in 3D culture models provide insights into immune-epithelial interactions in CRC.
- Patient-derived tumoroids show potential for personalized CRC therapies.
- Murine models aid in understanding inflammatory pathways' contribution to CRC.
Conclusions:
- Inflammation is a significant factor in sporadic colorectal cancer.
- 3D culture systems and murine models are valuable tools for CRC research.
- New therapeutic strategies and biomarkers for CRC are emerging from inflammation research.
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