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Evaluation of a bioengineered construct for tissue engineering applications.

Perla Ayala¹, Erbin Dai¹, Michael Hawes²

¹Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

|November 14, 2017

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New bioengineered collagen scaffolds show promise for tissue repair, matching commercial biologic mesh performance. These collagen-based materials offer potential for load-bearing tissue engineering applications.

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Effective biomaterials for tissue repair and regeneration are limited.
Current biologic meshes are decellularized tissues from various sources.
There is a need for advanced bioengineered constructs for abdominal defect repair.

Purpose of the Study:

To evaluate two novel collagen-based bioengineered constructs against a commercial biologic mesh.
To assess the efficacy of these constructs in a model of abdominal full-thickness defect repair.

Main Methods:

Developed two collagen-based constructs: one pure collagen sheet construct and another with RGD-functionalized alginate gel.
Utilized acid-solubilized collagen type 1 from porcine skin.

Keywords:

Veritas alginate full thickness abdominal defect integration and vascularization porcine collagen

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Laser micropatterning was used to create pores for tissue integration.

Compared constructs against a bovine pericardium-derived commercial mesh (Veritas®) in an abdominal defect model.

Main Results:

Enhanced vascularization was observed in the collagen-alginate construct at 2 weeks post-implantation.
Both bioengineered constructs demonstrated performance comparable to the commercial mesh.
Similar integration strength was achieved by the engineered constructs and the commercial product at 8 weeks.

Conclusions:

Bioengineered constructs derived from monomeric collagen show significant potential for tissue engineering.
These constructs offer promising alternatives for load-bearing applications in tissue repair and regeneration.
The collagen-alginate construct exhibited enhanced early vascularization, suggesting improved bioactive properties.