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Taming the Beast: Control of APC/CCdc20-Dependent Destruction
Pablo Lara-Gonzalez1,2, Taekyung Kim1,2, Arshad Desai1,2
1Ludwig Institute for Cancer Research, La Jolla, California 92093.
Cold Spring Harbor Symposia on Quantitative Biology
|November 15, 2017
Summary
The anaphase-promoting complex/cyclosome (APC/C) controls cell division timing. Chromosomal pathways precisely regulate APC/C activity via Cdc20, ensuring accurate genome partitioning during mitosis.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- The anaphase-promoting complex/cyclosome (APC/C) is a crucial ubiquitin ligase.
- It regulates the cell cycle, specifically the transition from metaphase to anaphase.
- APC/C activity requires the coactivator Cdc20 to degrade cyclin B and securin.
Purpose of the Study:
- To discuss regulatory mechanisms controlling APC/CCdc20 activity.
- To highlight the role of chromosomal pathways in modulating APC/C activation.
- To explain how precise control ensures accurate cell division.
Main Methods:
- Literature review and discussion of existing research.
- Focus on chromosomal pathways influencing APC/CCdc20.
- Analysis of mechanisms that accelerate or delay APC/C activation.
Main Results:
- APC/CCdc20 activity is tightly regulated before and during mitosis.
- Chromosomal pathways play a key role in controlling Cdc20's fate.
- These pathways ensure timely and accurate cell cycle progression.
Conclusions:
- The regulation of APC/CCdc20 is essential for faithful genome segregation.
- Understanding these control mechanisms provides insight into cell cycle fidelity.
- Precise regulation ensures accurate and timely cell division.
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