Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

14.5K
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
14.5K
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

1.4K
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
1.4K
Atomic Force Microscopy01:08

Atomic Force Microscopy

4.6K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
4.6K
Infrared (IR) Spectroscopy: Overview01:09

Infrared (IR) Spectroscopy: Overview

5.3K
When electromagnetic radiation passes through a material, atoms or molecules transition from a lower to a higher energy state by absorbing radiation corresponding to the energy difference between the two states. The absorption of infrared (IR) radiation causes transitions between vibrational energy levels in a molecule. Therefore, IR spectroscopy is a useful analytical tool for determining the molecular structure of molecules.
Different compounds display unique properties due to their...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The piezoionic diode: field-driven amplification of mechano-ionic conversion.

Materials horizons·2026
Same author

Design and validation of an electroporation-capable random positioning machine for the study of cell membrane permeabilization in simulated microgravity.

The Review of scientific instruments·2026
Same author

Real-time processing of high-throughput quantitative phase microscopy data using a Jetson Orin Nano.

Biophotonics discovery·2026
Same author

Enhanced penetration depth in optical coherence tomography and photoacoustic microscopy <i>in vivo</i> enabled by absorbing dye molecules.

Optica·2026
Same author

Prospective Identification of Dysplasia in Barrett's Esophagus With Combined Optical Coherence Tomography and Light Scattering Measurements.

Journal of biophotonics·2025
Same author

High-fidelity microsecond-scale cellular imaging using two-axis compressed streak imaging fluorescence microscopy.

ArXiv·2025
Same journal

Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver.

Optics letters·2026
Same journal

E2E-OCT: end-to-end joint learning model using optical coherence tomography images for vocal cord leukoplakia diagnosis.

Optics letters·2026
Same journal

Holographic generation of panoramic 3D scenes by concave ellipsoidal mirror reflection.

Optics letters·2026
Same journal

Dual-pilot phase recovery with pair-wise maximum-ratio combining for coherent PONs.

Optics letters·2026
Same journal

Mapping the whispering gallery modes of a CaF<sub>2</sub> disk resonator with half-tapered fibers to estimate the fundamental mode volume.

Optics letters·2026
Same journal

Quantitative estimation of deep-subwavelength scale via dark-field scattering axial energy concentration decay profiles.

Optics letters·2026
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

9.0K

Scanning system for angle-resolved low-coherence interferometry.

Zachary A Steelman, Derek Ho, Kengyeh K Chu

    Optics Letters
    |November 16, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Angle-resolved low-coherence interferometry (a/LCI) now screens wider areas for precancer detection. This new scanning method assesses over 100 mm² without probe repositioning, enhancing diagnostic capabilities.

    More Related Videos

    Three-dimensional Super Resolution Microscopy of F-actin Filaments by Interferometric PhotoActivated Localization Microscopy iPALM
    11:57

    Three-dimensional Super Resolution Microscopy of F-actin Filaments by Interferometric PhotoActivated Localization Microscopy iPALM

    Published on: December 1, 2016

    11.2K
    Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating
    10:39

    Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating

    Published on: October 11, 2016

    10.2K

    Related Experiment Videos

    Last Updated: Feb 18, 2026

    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
    12:22

    Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

    Published on: August 4, 2018

    9.0K
    Three-dimensional Super Resolution Microscopy of F-actin Filaments by Interferometric PhotoActivated Localization Microscopy iPALM
    11:57

    Three-dimensional Super Resolution Microscopy of F-actin Filaments by Interferometric PhotoActivated Localization Microscopy iPALM

    Published on: December 1, 2016

    11.2K
    Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating
    10:39

    Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating

    Published on: October 11, 2016

    10.2K

    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Cancer Diagnostics

    Background:

    • Angle-resolved low-coherence interferometry (a/LCI) enables in vivo nuclear morphology measurements for precancer detection.
    • Current a/LCI methods are limited by their point-probe nature, restricting sampled area (<0.5 mm²).
    • Probe relocation is required for comprehensive tissue assessment, hindering efficiency.

    Purpose of the Study:

    • To develop a scanning method for a/LCI to overcome area limitations.
    • To enable wide-area tissue screening without probe repositioning.
    • To enhance the diagnostic utility of a/LCI for early precancer detection.

    Main Methods:

    • Implemented a reflection-only three-optic rotator prism.
    • Integrated a two-axis scanning mirror for sample manipulation.
    • Demonstrated radial scanning with a 12 mm linear range and 180° rotational range.

    Main Results:

    • Achieved area assessment exceeding 100 mm² without repositioning the probe.
    • Successfully demonstrated radial scanning capabilities.
    • Validated the effectiveness of the new scanning mechanism for a/LCI.

    Conclusions:

    • The developed scanning method significantly expands the area coverage of a/LCI.
    • This advancement improves the efficiency and diagnostic potential of a/LCI for wide-area tissue screening.
    • The enhanced a/LCI system offers improved utility for detecting precancerous changes in tissues.