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Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function
Shibu M Poulose1, Marshall G Miller1, Tammy Scott1
1USDA-ARS Human Nutrition Research Center on Aging at Tufts University, Neuroscience and Aging Laboratory, Boston, MA.
Advances in Nutrition (Bethesda, Md.)
|November 17, 2017
Summary
Diet significantly impacts adult neurogenesis, the creation of new brain cells in the hippocampus. Nutritional strategies show promise for enhancing brain cell growth and combating cognitive decline associated with aging and disease.
Area of Science:
- Neuroscience
- Nutritional Science
- Cell Biology
Background:
- Adult neurogenesis is vital for cognitive function, brain repair, and homeostasis.
- This process, occurring in the hippocampus, is influenced by numerous intrinsic and extrinsic factors.
- Aging, neuroinflammation, and unhealthy diets negatively impact neurogenesis.
Purpose of the Study:
- To review the role of nutritional factors in modulating adult neurogenesis.
- To explore the potential of dietary interventions for preserving cognitive function during aging.
- To highlight nutritional approaches for combating neurodegenerative diseases.
Main Methods:
- Literature review of studies on diet and adult neurogenesis.
- Analysis of evidence linking specific nutrients and dietary patterns to neurogenesis.
- Synthesis of findings on mechanisms and outcomes.
Main Results:
- Various dietary components (curcumin, resveratrol, polyphenols, PUFAs) and diets (enriched, caloric restriction) promote adult neurogenesis.
- Lifestyle factors like exercise and learning also induce neurogenesis.
- Negative impacts observed from high-fat/sugar diets and substance addiction.
Conclusions:
- Nutritional factors play a significant role in regulating adult neurogenesis.
- Dietary interventions offer a promising strategy to enhance cognitive function and mitigate age-related cognitive decline.
- Further research into underlying mechanisms can optimize nutritional approaches for brain health.
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