Related Experiment Video

Updated: Feb 18, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Kidney Cancer: Current Progress in Treatment

Ankita Thakur1, Sunil K Jain1

  • 1Faculty of Pharmacy, Adina Institute of Pharmaceutical Sciences, Sagar, M.P. - 470002, India.

World Journal of Oncology
|November 18, 2017
PubMed

Insights

Kidney cancer, primarily renal cell carcinoma, is increasing globally. New targeted therapies and immunotherapies offer survival benefits for select patients with advanced disease.

Area of Science:

  • Oncology
  • Nephrology
  • Cancer Biology

Background:

  • Kidney cancer represents 2% of global cancer diagnoses, with rising incidence and mortality.
  • Renal cell carcinoma (RCC) is the predominant histological subtype.
  • Key risk factors include smoking, obesity, and genetic predispositions.

Purpose of the Study:

  • To review current understanding of kidney cancer epidemiology and risk factors.
  • To summarize advancements in targeted therapies and immunotherapies for metastatic RCC.
  • To highlight emerging molecular pathways and treatment strategies.

Main Methods:

  • Review of epidemiological data on kidney cancer incidence and mortality.
  • Analysis of clinical trial outcomes for novel therapeutic agents in metastatic RCC.
  • Exploration of molecular pathways implicated in RCC pathogenesis.

Main Results:

  • Immunotherapy provides a survival advantage in a subset of metastatic RCC patients (approx. 20%) with specific predictive markers.
  • Small molecule inhibitors (sunitinib, sorafenib, temsirolimus) and monoclonal antibodies (bevacizumab) demonstrate anti-tumor activity.
  • These agents have become standard of care for many patients with advanced RCC.

Conclusions:

  • Targeted therapies and immunotherapies represent significant progress in managing advanced kidney cancer.
  • Further research into molecular pathways may identify new therapeutic targets.
  • Personalized treatment approaches based on predictive characteristics are crucial for optimizing outcomes in RCC.
Keywords:
ImmunotherapyKidney cancerNephrectomySorafenibSunitinib

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