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Updated: Feb 18, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

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[Effects of antibiotics on intestinal microflora and intestinal mucosal barrier function and its mechanisms]

Yue Han1, Yuxin Leng, Gaiqi Yao

  • 1Department of Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China. Corresponding author: Yao Gaiqi,

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|November 21, 2017
PubMed

Insights

Antibiotics harm gut microbes, causing dysfunction and damage. Probiotics and fecal transplants can restore intestinal health by promoting beneficial bacteria, supporting rational antibiotic use.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Pharmacology

Background:

  • Antibiotics are crucial for infectious diseases but disrupt intestinal microflora, leading to gastrointestinal issues like diarrhea and mucosal damage.
  • Severe antibiotic-induced disruption can progress to intestinal sepsis, highlighting the need for understanding these effects.
  • Advancements in microbial sequencing and the Human Microbiome Project offer deeper insights into antibiotic impacts on gut flora.

Purpose of the Study:

  • To detail the effects and mechanisms of antibiotics on intestinal microflora and mucosal barrier function.
  • To explore therapeutic strategies for mitigating antibiotic-induced gut dysbiosis.
  • To promote the rational application of antibiotics in clinical practice.

Main Methods:

  • Review and analysis of existing research on antibiotic effects on the gut microbiome.
  • Examination of the impact on intestinal mucosal barrier integrity.
  • Evaluation of probiotics and fecal microbiota transplantation as therapeutic interventions.

Main Results:

  • Antibiotics significantly alter the composition and function of the intestinal microflora.
  • Damage to the intestinal mucosal barrier is a common consequence of antibiotic treatment.
  • Probiotics and fecal transplantation show promise in restoring gut microbial balance and barrier function.

Conclusions:

  • Antibiotic-induced gut dysbiosis poses significant health risks, necessitating interventions.
  • Restoring a healthy gut microbiome through strategies like probiotics and fecal transplantation is feasible.
  • These findings support the rational use of antibiotics and the development of microbiome-targeted therapies.

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