Intraoperative Injection vs Sponge-applied Mitomycin C during Trabeculectomy: One-year Study.

Area of Science:

• Ophthalmology
• Glaucoma Surgery
• Ocular Pharmacology

Background:

• Trabeculectomy is a common glaucoma surgery.
• Mitomycin C (MMC) is used to enhance surgical success.
• Traditional MMC application uses sponges.

Purpose of the Study:

• To compare the safety and efficacy of intraoperative mitomycin C (MMC) injection versus sponge application during trabeculectomy.
• To evaluate intraocular pressure (IOP) reduction, treatment success, and postoperative complications.

Main Methods:

• Retrospective, comparative case series of 60 eyes (30 injection, 30 sponge).
• Data collected preoperatively and up to 1 year postoperatively.
• Key metrics included IOP, visual acuity, medication use, and interventions.

Main Results:

• Both methods achieved significant IOP reduction at 1 year.
• Injection group had lower postoperative IOP and comparable complete treatment success.
• Injection group required fewer postoperative visits and 5-fluorouracil (5-FU) interventions.

Conclusions:

• Intraoperative MMC injection is a safe and effective alternative to sponge application in trabeculectomy.
• Offers comparable efficacy with potential advantages in reduced follow-up and interventions.
• Further prospective studies are warranted to confirm long-term outcomes.