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Ebola virus disease: an update on post-exposure prophylaxis
William A Fischer1, Pauline Vetter2, Daniel G Bausch3
1Division of Pulmonary and Critical Care Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
The Lancet. Infectious Diseases
|November 21, 2017
Summary
Post-exposure prophylaxis offers immediate protection against Ebola virus disease, crucial for limiting transmission and protecting healthcare workers. This review advances understanding and proposes guidance for its use in future outbreaks.
Area of Science:
- Infectious Diseases
- Public Health
- Epidemiology
Background:
- The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa spurred evaluation of countermeasures.
- Preclinical research led to the first clinical trials for EVD therapeutics and vaccines.
Purpose of the Study:
- To review the understanding of post-exposure prophylaxis (PEP) for Ebola virus infection.
- To propose provisional guidance for PEP use in EVD.
- To identify priorities for future preparedness and research.
Main Methods:
- Review of data and experience from the West Africa EVD outbreak.
- Analysis of the efficacy of countermeasures for post-exposure prophylaxis.
- Development of provisional guidance for PEP in EVD.
Main Results:
- Experience from the outbreak advanced the understanding of PEP efficacy.
- PEP can provide more immediate protection than immunization.
- PEP offers additional protection for exposed healthcare workers.
Conclusions:
- Post-exposure prophylaxis is a vital tool for reducing EVD transmission.
- PEP enhances protection for healthcare workers and the general population.
- Further research and preparedness are essential for effective EVD response.
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