Remodeling the Tumor Microenvironment with Emerging Nanotherapeutics
Qin Chen1, Guangxuan Liu1, Shuo Liu1
1Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Number 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, PR China.
Trends in Pharmacological Sciences
|November 21, 2017
Summary
Nanomedicine advances TME modulation for cancer therapy. This review details nanotherapeutic strategies for remodeling the tumor microenvironment (TME) by targeting extracellular matrix, fibroblasts, vasculature, and hypoxia.
Area of Science:
- Oncology
- Nanomedicine
- Biotechnology
Background:
- The tumor microenvironment (TME) significantly influences cancer progression.
- Remodeling the TME is a promising strategy to enhance cancer therapy efficacy.
- Nanomedicine offers novel tools for TME modulation.
Purpose of the Study:
- To review recent advances in TME remodeling using nanotherapeutics.
- To highlight strategies targeting key TME components.
- To discuss emerging nanomedical approaches for overcoming therapeutic resistance.
Main Methods:
- Review of current literature on nanotherapeutics for TME modulation.
- Categorization of strategies based on targeted TME components (ECM, TAFs, vasculature, hypoxia).
- Analysis of nanomedicine applications in disrupting or normalizing TME features.
Main Results:
- Novel nanotherapeutic strategies for modulating tumor extracellular matrix (ECM) fabrication.
- Emerging nanotherapeutics targeting tumor-associated fibroblasts (TAFs).
- Recent developments in nanomedicine for tumor vessel normalization and hypoxia management.
Conclusions:
- Nanotherapeutics provide powerful tools for TME remodeling.
- Targeting ECM, TAFs, vasculature, and hypoxia with nanomedicine shows therapeutic potential.
- Continued research in nanomedicine is crucial for advancing cancer treatment by TME modulation.
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