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Published on: March 18, 2019
Development of an inhalation reference concentration for diethanolamine.
Joseph T Haney1, Darrell McCant1, Michael E Honeycutt1
1Texas Commission on Environmental Quality (TCEQ), Toxicology Division, MC-168, P.O. Box 13087, Austin, TX, 78711, United States.
A new inhalation reference concentration (RfC) for diethanolamine (DEA) was established at 25 μg/m³. This value, derived from animal studies, aims to protect the general population from potential long-term environmental exposure risks.
Area of Science:
- Environmental Health
- Toxicology
- Risk Assessment
Background:
- Diethanolamine (DEA) is a chemical compound with potential health implications.
- Establishing safe exposure limits is crucial for public health protection.
Purpose of the Study:
- To develop an inhalation reference concentration (RfC) for diethanolamine (DEA).
- To assess the potential health effects of long-term environmental exposure to DEA.
Main Methods:
- Utilized three key animal studies (Gamer et al., 1993, 1996, 2008) for analysis.
- Identified increased relative liver weight in female rats as the critical effect.
- Applied uncertainty factors to derive a health-protective exposure limit.
Main Results:
- Established an inhalation reference concentration (RfC) of 25 μg/m³ for DEA.
- The critical effect was statistically significant increased relative liver weight in female rats.
- Laryngeal effects were observed but at higher exposure levels than liver effects.
Conclusions:
- The developed RfC of 25 μg/m³ is considered health protective for the general population.
- This RfC can be used for evaluating long-term environmental exposure to DEA.
- The study provides a basis for risk assessment and management of DEA exposure.
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